High-sensitive Troponin is a laboratory test routinely done on patients suspected to have myocardial infarction (MI). High-sensitivity troponin assays have greatly improved the analytical performance of conventional cardiac troponin T and I testing. In many African countries, clinical laboratory reference intervals have not been established, and Western country-based reference intervals are usually used in many diagnostic laboratories and clinical trials to screen, diagnose, and monitor different disease states. In a country like Kenya, almost all available clinical laboratories rely on reference intervals obtained either from textbooks or from the package kit inserts provided by the manufacturers. The considerable differences in the established reference intervals in several countries and population groups may increase the chance of unnecessary additional investigations, failure to detect the specified abnormalities related to underlying disease states or mismanagement of patient