Dr. Kruger's research focuses on the physiological effects of gender-affirming hormone therapy (GAHT) on diverse body systems using mouse models. Much is still unknown about the effects of GAHT on metabolism, cardiovascular health, and reproductive outcomes, partially because controlled studies of GAHT cannot be ethically performed in human patients. Transgender, non-binary, and gender-diverse patients also experience many psychosocial stressors not experienced by cis-gendered patients, presenting potentially confounding factors in case-control studies. Dr. Kruger uses a mouse model of adult and adolescent GAHT to overcome these limitations. Currently, her research explores the effect of GAHT and gender-affirming surgery on metabolic outcomes. She is also investigating metabolic and reproductive outcomes in offspring of T-treated mice.